Cobalt‐Catalyzed Hydrogenation and Deuteration Reactions of Bicyclic Alkenes in an Aqueous Environment
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Published:2024-01-27
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Volume:
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ISSN:1434-193X
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Container-title:European Journal of Organic Chemistry
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language:en
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Short-container-title:Eur J Org Chem
Author:
Pounder Austin1,
van der Zalm Joshua1,
Chen Aicheng1,
Tam William2
Affiliation:
1. University of Guelph Chemistry CANADA
2. University of Guelph Department of Chemistry Chemistry Building N1G 2W1 Guelph CANADA
Abstract
Herein, we report cobalt‐catalyzed hydrogenation and deuteration reactions of bicyclic alkenes using H2O and D2O as the sole hydrogen and deuterium sources, respectively, employing Zn or Mn as a metal reductant. Lewis‐acid co‐catalysts were found to promote the reaction whilst simultaneously catalyzing transesterification processes. Use of 1 atm of H2 allows for catalytic loading of the metal reductant. In all cases, the reaction operated with high functional‐group tolerance and produced the reduced products in high yield.
Subject
Organic Chemistry,Physical and Theoretical Chemistry