Basicity‐Controlled [3+2] Cyclization of 3‐Hydroxyquinolin‐ones and β‐Chlorinated Nitrostyrenes-Reference-Cited by-同舟云学术

Basicity‐Controlled [3+2] Cyclization of 3‐Hydroxyquinolin‐ones and β‐Chlorinated Nitrostyrenes

Published:2023-05-22 Issue:22 Volume:26 Page:
ISSN:1434-193X
Container-title:European Journal of Organic Chemistry
language:en
Short-container-title:Eur J Org Chem

Author:

Wu Jiamin¹,Hu Fei¹,Bai Guishun¹,Yang Yang¹,Bonne Damien²,Rodriguez Jean²,Yue Congyong³,Wang Hong¹⁴^ORCID,Bao Xiaoze¹⁴^ORCID

Affiliation:

1. College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals Zhejiang University of Technology Hangzhou 310014 P. R. China

2. CNRS Aix Marseille Université Centrale Marseille iSm2 Marseille France

3. Shaoxing Minsheng Pharmaceutical Co., Ltd. Shaoxing 312071 P. R. China

4. Zhejiang International Sci-Tech Cooperation Base for the Exploitation and Utilization of Nature Product Hangzhou 310014 P. R. China

Abstract

AbstractThe construction of novel skeletons through the recombination of natural products ring systems is attractive. Herein, a basicity‐controlled synthesis of (dihydro)furo[2,3‐c]quinolin‐4(5H)‐one derivatives through (3+2) cyclization between 3‐hydroxyquinolin‐2‐ones and β‐chlorinated nitrostyrenes was developed. In addition, preliminary study gave the chiral dihydrofuro[2,3‐c]quinolin‐4(5H)‐one derivatives with up to 83 % ee.

Funder

National Key Research and Development Program of China

Department of Education of Zhejiang Province

Publisher

Wiley

Subject

Organic Chemistry,Physical and Theoretical Chemistry

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