Affiliation:
1. State Key Laboratory of Fine Chemicals Department of Pharmaceutical Engineering School of Chemical Engineering Dalian University of Technology 2 Linggong Road Dalian 116024 China
Abstract
AbstractA catalytic asymmetric (3+2) cyclization of pyrazolone‐based MBH adducts with alkylidenyl isoxazolones was presented by using DMAP‐derived chiral catalyst, affording bis‐spirocyclic pyrazolones bearing vicinal all‐carbon quaternary stereocenters within an imbedded cyclopentene ring scaffold in good yields with excellent stereoselectivities under mild conditions.
Funder
Fundamental Research Funds for the Central Universities