Affiliation:
1. Faculty of Chemistry University of Warsaw 02-093 Warsaw Pasteura 1 Poland
Abstract
AbstractHere we present a systematic analysis of the synthesis of unsymmetrical disulphides employing 6‐thioguanosine and its mono‐ and dinucleotides by three of the most common strategies: a nucleophilic substitution of the thiol, a thiol exchange reaction with another disulphide and oxidative dehydrogenation coupling reactions of S−H bonds. The exchange reaction was found to be the most efficient approach and could be used not only for nucleosides but also for nucleotides.