Affiliation:
1. Key Laboratory of Functional Molecular Engineering of Guangdong Province School of Chemistry and Chemical Engineering South China University of Technology Guangzhou 510640 China
2. School of Pharmacy Guangdong Medical University Dongguan 523808 China
Abstract
Abstractα‐Methylene‐γ‐butyrolactone is an important skeleton in many natural products and pharmaceuticals. The factors influencing the palladium‐catalyzed asymmetric synthesis of α‐chloromethylene‐γ‐butyrolactones were investigated, including ligands, additives, the chlorine source, temperature, and solvents. We found that the reaction had broad substrate scope for the synthesis of the corresponding chiral products when the ligand, chlorine source and additives were optimized. The results will improve the catalytic synthesis of chiral α‐chloromethylene‐γ‐butyrolactones.
Funder
National Natural Science Foundation of China
Subject
Organic Chemistry,Physical and Theoretical Chemistry