Affiliation:
1. Gordon Center for Medical Imaging, Massachusetts General Hospital &Department of Radiology Harvard Medical School Boston MA USA
2. Martinos Center for Biomedical Imaging, Massachusetts General Hospital & Department of Radiology Harvard Medical School Boston Massachusetts USA
Abstract
We report here the detailed radiosynthesis of [18F]mG4P027, a metabotropic glutamate receptor 4 (mGluR4) PET radiotracer, which showed superior properties to the currently reported mGluR4 radiotracers. The radiosynthesis in the automated system has been challenging, therefore we disclose here the major limiting factors for the synthesis via step‐by‐step examination. And we hope this thorough study will help its automation for human use in the future.
Funder
National Center for Advancing Translational Sciences
Subject
Organic Chemistry,Spectroscopy,Drug Discovery,Radiology, Nuclear Medicine and imaging,Biochemistry,Analytical Chemistry
Cited by
4 articles.
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