Initial testing (stage 1) of eribulin, a novel tubulin binding agent, by the pediatric preclinical testing program

Author:

Kolb E. Anders1,Gorlick Richard2,Reynolds C. Patrick3,Kang Min H.3,Carol Hernan4,Lock Richard4,Keir Stephen T.5,Maris John M.6,Billups Catherine A.7,DesJardins Christopher8,Kurmasheva Raushan T.9,Houghton Peter J.9,Smith Malcolm A.10

Affiliation:

1. A.I. duPont Hospital for Children; Wilmington, Delaware

2. The Children's Hospital at Montefiore; Bronx, New York

3. Texas Tech University Health Sciences Center; Lubbock, Texas

4. Children's Cancer Institute Australia for Medical Research; Randwick, New South Wales; Australia

5. Duke University Medical Center; Durham, North Carolina

6. Children's Hospital of Philadelphia; University of Pennsylvania School of Medicine and Abramson Family Cancer Research Institute; Philadelphia, Pennsylvania

7. St. Jude Children's Research Hospital; Memphis, Tennessee

8. Eisai, Inc.; Andover, Massachusetts

9. Nationwide Children's Hospital; Columbus, Ohio

10. Cancer Therapy Evaluation Program; NCI; Bethesda, Maryland

Publisher

Wiley

Subject

Oncology,Hematology,Pediatrics, Perinatology and Child Health

Reference42 articles.

1. Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data;Bai;J Biol Chem,1991

2. In vitro and in vivo anticancer activities of synthetic macrocyclic ketone analogues of halichondrin B;Towle;Cancer Res,2001

3. Microtubules as a target for anticancer drugs;Jordan;Nat Rev Cancer,2004

4. Eribulin binds at microtubule ends to a single site on tubulin to suppress dynamic instability;Smith;Biochemistry,2010

5. The primary antimitotic mechanism of action of the synthetic halichondrin E7389 is suppression of microtubule growth;Jordan;Mol Cancer Ther,2005

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