The Hepatic Sinusoid is Not Well-Stirred: Estimation of the Degree of Axial Mixing by Analysis of Lobular Concentration Gradients Formed During Uptake of Thyroxine by the Perfused Rat Liver-Reference-Cited by-同舟云学术

The Hepatic Sinusoid is Not Well-Stirred: Estimation of the Degree of Axial Mixing by Analysis of Lobular Concentration Gradients Formed During Uptake of Thyroxine by the Perfused Rat Liver

Published:1986-03 Issue:3 Volume:75 Page:233-237
ISSN:0022-3549
Container-title:Journal of Pharmaceutical Sciences
language:en
Short-container-title:Journal of Pharmaceutical Sciences

Author:

Weisiger Richard A.,Mendel Carl M.,Cavalieri Ralph R.

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference28 articles.

1. Circulatory Pathways in the Rat Liver as Revealed by P32 Chromic Phosphate Colloid Uptake in the Isolated Perfused Liver Preparation

2. Altered Hepatic Blood Flow and Drug Disposition1

3. Hepatic clearance of drugs. I. Theoretical considerations of a “well-stirred” model and a “parallel tube” model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance

4. Hepatic clearance of drugs. II. Experimental evidence for acceptance of the “well-stirred” model over the “parallel tube” model using lidocaine in the perfused rat liverin situ preparation

5. Hepatic clearance of drugs. III. Additional experimental evidence supporting the “wellstirred” model, using metabolite (MEGX) generated from lidocaine under varying hepatic blood flow rates and linear conditions in the perfused rat liverin situ preparation

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