Hunting for the high‐affinity state of G‐protein‐coupled receptors with agonist tracers: Theoretical and practical considerations for positron emission tomography imaging

Author:

Shalgunov Vladimir1ORCID,van Waarde Aren1ORCID,Booij Jan2,Michel Martin C.3,Dierckx Rudi A. J. O.14,Elsinga Philip H.1

Affiliation:

1. Department of Nuclear Medicine and Molecular ImagingUniversity Medical Center Groningen, University of GroningenGroningen The Netherlands

2. Department of Radiology and Nuclear MedicineAmsterdam University Medical Centers, Academic Medical Center, University of AmsterdamAmsterdam The Netherlands

3. Department of PharmacologyJohannes Gutenberg UniversityMainz Germany

4. Department of Nuclear MedicineGhent University, University HospitalGhent Belgium

Funder

Dutch Technology Foundation

Publisher

Wiley

Subject

Drug Discovery,Pharmacology,Molecular Medicine

Reference236 articles.

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2. Structural insights into agonist-induced activation of G-protein-coupled receptors

3. Anterior pituitary dopamine receptors. Demonstration of interconvertible high‐ and low‐affinity states of the D‐2 dopamine receptor;Sibley DR;J Biol Chem,1982

4. Interactions of dopamine agonists with brain D1 receptors labeled by 3H‐antagonists. Evidence for the presence of high‐ and low‐affinity agonist‐binding states;Leff SE;Mol Pharmacol,1985

5. Guanyl Nucleotide and Divalent Cation Regulation of Cortical S2Serotonin Receptors

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