Population Pharmacokinetic Modeling With Enterohepatic Circulation for AZD3241 in Healthy Subjects and Patients With Multiple System Atrophy-Reference-Cited by-同舟云学术

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Population Pharmacokinetic Modeling With Enterohepatic Circulation for AZD3241 in Healthy Subjects and Patients With Multiple System Atrophy

Published:2018-06-06 Issue:11 Volume:58 Page:1452-1460
ISSN:0091-2700
Container-title:The Journal of Clinical Pharmacology
language:en
Short-container-title:The Journal of Clinical Pharmacology

Author:

Tong Xiao¹^ORCID,Zhou Diansong¹,Savage Alicia²,Mullen Jamie A.²,Li Yan³,Taylor Wendy⁴,Li Jianguo¹,Al-Huniti Nidal¹,Xu Hongmei¹

Affiliation:

1. Quantitative Clinical Pharmacology, Early Clinical Development; IMED Biotech Unit, AstraZeneca; Boston MA USA

2. Neuroscience; IMED Biotech Unit, AstraZeneca; Boston MA USA

3. Early Clinical Development; IMED Biotech Unit, AstraZeneca; Boston MA USA

4. Personalized Healthcare & Biomarkers; IMED Biotech Unit, AstraZeneca; Gothenburg Sweden

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/jcph.1134/fullpdf

Reference15 articles.

1. Multiple system atrophy as emerging template for accelerated drug discovery in alpha-synucleinopathies;Krismer;Parkinsonism Relat Disord,2014

2. Myeloperoxidase polymorphism is associated with gender specific risk for Alzheimer's disease;Reynolds;Exp Neurol,1999

3. Targeted overexpression of human alpha-synuclein in oligodendroglia induces lesions linked to MSA-like progressive autonomic failure;Stemberger;Exp Neurol,2010

4. Development of rapid multistep carbon-11 radiosynthesis of the myeloperoxidase inhibitor AZD3241 to assess brain exposure by PET microdosing;Johnstrom;Nucl Med Biol,2015

5. Population pharmacokinetics of naloxegol in a population of 1247 healthy subjects and patients;Al-Huniti;Br J Clin Pharmacol,2016

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1. Prediction of the liver safety profile of a first-in-class myeloperoxidase inhibitor using quantitative systems toxicology modeling;Xenobiotica;2024-08-08

2. Multiple system atrophy: an update and emerging directions of biomarkers and clinical trials;Journal of Neurology;2024-03-14

3. Discovery of a novel, highly potent and orally bioavailable pyrrolidinone indole series of irreversible Myeloperoxidase (MPO) inhibitors;Biochemical Pharmacology;2023-03

4. Discovery of a Novel, Highly Potent and Orally Bioavailable Pyrrolidinone Indole Series of Irreversible Myeloperoxidase (MPO) Inhibitors;SSRN Electronic Journal;2022

5. Neutrophil Extracellular Trap Density Increases With Increasing Histopathological Severity of Crohn’s Disease;Inflammatory Bowel Diseases;2021-11-01

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