In silico analysis of structural modifications in and around the integrin αIIb genu caused byITGA2Bvariants in human platelets with emphasis on Glanzmann thrombasthenia-Reference-Cited by-同舟云学术

In silico analysis of structural modifications in and around the integrin αIIb genu caused byITGA2Bvariants in human platelets with emphasis on Glanzmann thrombasthenia

Published:2018-01-31 Issue:2 Volume:6 Page:249-260
ISSN:2324-9269
Container-title:Molecular Genetics & Genomic Medicine
language:en
Short-container-title:Mol Genet Genomic Med

Author:

Pillois Xavier¹²,Peters Pierre³,Segers Karin⁴,Nurden Alan T.²^ORCID

Affiliation:

1. Institut de Rhythmologie et de Modélisation Cardiaque, Plateforme Technologique d'Innovation Biomédicale; Hôpital Xavier Arnozan; Bordeaux France

2. Université de Bordeaux; INSERM U1034; Bordeaux France

3. Laboratoire de Thrombose-Hémostase; Service d'Hématologie biologique et Immuno-Hématologie; CHU Sart Tilman; Liège Belgium

4. Service de Génetique; CHU Sart Tilman; Liège Belgium

Funder

Institut National de la Santé et de la Recherche Médicale

Publisher

Wiley

Subject

Genetics (clinical),Genetics,Molecular Biology

Reference54 articles.

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3. Effects of limiting extension at the alphaIIb genu on ligand binding to integrin alphaIIbbeta3;Blue;Journal of Biological Chemistry,2010

4. 4151 αIIbβ3 variants defined by next-generation sequencing: Predicting variants likely to cause Glanzmann thrombasthenia;Buitrago;Proceedings of the National Academy of Sciences of the United States of America,2015

5. Structure of human platelet membrane glycoproteins IIb and IIIa as determined by electron microscopy;Carrell;Journal of Biological Chemistry,1985

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