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Response to tumor necrosis factor-α mediated inflammation involving activation of prostaglandin E2 and Wnt signaling in nucleus pulposus cells

  • Published:2015-07-14 Issue:12 Volume:33 Page:1756-1768
  • ISSN:0736-0266
  • Container-title:Journal of Orthopaedic Research
  • language:en
  • Short-container-title:J. Orthop. Res.

Author:

Hiyama Akihiko12,Yokoyama Katsuya12,Nukaga Tadashi12,Sakai Daisuke12,Mochida Joji12

Affiliation:

1. Department of Orthopaedic Surgery, Surgical Science; Tokai University School of Medicine; 143 Shimokasuya, Isehara, Kanagawa 259-1193 Japan

2. Research Center for Regenerative Medicine; Tokai University School of Medicine; 143 Shimokasuya, Isehara, Kanagawa 259-1193 Japan

Publisher

Wiley

Subject

Orthopedics and Sports Medicine

Reference47 articles.

1. The development and growth of the intervertebral disc;Walmsley;Edinburgh Med J,1953

2. Percutaneous reinsertion of the nucleus pulposus. An experimental study;Nishimura;Spine,1998

3. MEK/ERK signaling controls osmoregulation of nucleus pulposus cells of the intervertebral disc by transactivation of TonEBP/OREBP;Tsai;J Bone Miner Res,2007

4. Inflammatory and catabolic signalling in intervertebral discs: the roles of NF-kappaB and MAP kinases;Wuertz;Eur Cells Mater,2012

5. JAK/STAT but not ERK1/ERK2 pathway mediates interleukin (IL)-6/soluble IL-6R down-regulation of Type II collagen, aggrecan core, and link protein transcription in articular chondrocytes. Association with a down-regulation of SOX9 expression;Legendre;J Biol Chem,2003
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