Development and validation of LC–MS/MS method for amlexanox in rat plasma and its application in preclinical pharmacokinetics

Author:

Chen Dan1,Du Kaixin1,Niu Xiaochen1,Zhang Hongwei12,Zhang Xue1,Tang Yu12,Zhao Jianchun12ORCID

Affiliation:

1. School of Medicine and Pharmacy Ocean University of China Qingdao China

2. Marine Biomedical Research Institute of Qingdao Qingdao China

Funder

Fundamental Research Funds for the Central Universities

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Reference23 articles.

1. The treatment of chronic recurrent oral aphthous ulcers;Altenburg A.;Deutsches Ärzteblatt International,2014

2. Amlexanox for the Treatment of Recurrent Aphthous Ulcers

3. Amlexanox: A novel therapeutic for atopic, metabolic, and inflammatory disease;Dosanjh A.;The Yale Journal of Biology and Medicine,2020

4. A double‐blind study of topically applied 5% amlexanox in the treatment of aphthous ulcers;Greer R. O.;Journa of Oral Maxillofacial Surgery: Offical Journal of the American Association of Oral and Maxillofacial Surgeons,1993

5. Amlexanox exerts anti-inflammatory actions by targeting phosphodiesterase 4B in lipopolysaccharide-activated macrophages

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