Influence of OCT 1 Ontogeny and Genetic Variation on Morphine Disposition in Critically Ill Neonates: Lessons From PBPK Modeling and Clinical Study-Reference-Cited by-同舟云学术

Influence of OCT 1 Ontogeny and Genetic Variation on Morphine Disposition in Critically Ill Neonates: Lessons From PBPK Modeling and Clinical Study

Author:

Hahn David¹^ORCID,Emoto Chie¹²^ORCID,Euteneuer Joshua C.³⁴^ORCID,Mizuno Tomoyuki¹²^ORCID,Vinks Alexander A.¹²,Fukuda Tsuyoshi¹²^ORCID

Affiliation:

1. Division of Clinical Pharmacology Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA

2. Department of Pediatrics University of Cincinnati College of Medicine Cincinnati Ohio USA

3. Division of Neonatology Perinatal Institute Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA

4. Division of Neonatology Children's Hospital & Medical Center University of Nebraska Medical Center Omaha Nebraska USA

Funder

National Institutes of Health

Eunice Kennedy Shriver National Institute of Child Health and Human Development

Center for Clinical and Translational Science, University of Cincinnati

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

Reference27 articles.

5. Human UGT2B7 catalyzes morphine glucuronidation;Coffman B.L.;Drug Metab. Dispos.,1997

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