Assessment of Bile Salt Export Pump (BSEP) Inhibition in Membrane Vesicles Using Radioactive and LC/MS‐Based Detection Methods
Author:
Affiliation:
1. Hit Discovery and Optimization, Pfizer Inc Groton Connecticut
2. Primary Pharmacology Group, Pfizer Inc Groton Connecticut
Publisher
Wiley
Subject
Toxicology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/cptx.15
Reference25 articles.
1. Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump
2. Bile Acid Transporters: Structure, Function, Regulation and Pathophysiological Implications
3. Epidemiology of Idiosyncratic Drug-Induced Liver Injury
4. Use of Cryopreserved Human Hepatocytes in Sandwich Culture to Measure Hepatobiliary Transport
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