<scp>Cdt1</scp> overexpression drives colorectal carcinogenesis through origin overlicensing and <scp>DNA</scp> damage-Reference-Cited by-同舟云学术

Cdt1 overexpression drives colorectal carcinogenesis through origin overlicensing and DNA damage

Published:2022-11-09 Issue:1 Volume:259 Page:10-20
ISSN:0022-3417
Container-title:The Journal of Pathology
language:en
Short-container-title:The Journal of Pathology

Author:

Petropoulos Michalis¹²^ORCID,Champeris Tsaniras Spyridon¹^ORCID,Nikou Sofia³,Maxouri Styliani²^ORCID,Dionellis Vasilis S⁴,Kalogeropoulou Argyro²,Karamichali Angeliki⁴,Ioannidis Konstantinos²,Danalatos Iosif‐Rodolfos²,Obst Mandy⁵,Naumann Ronald⁶,Delinasios George J⁷,Gorgoulis Vassilis G⁸⁹¹⁰^ORCID,Roukos Vassilis¹¹,Anastassiadis Konstantinos⁵,Halazonetis Thanos D⁴,Bravou Vasiliki³,Lygerou Zoi²,Taraviras Stavros¹

Affiliation:

1. Department of Physiology, Medical School University of Patras Patras Greece

2. Department of General Biology, Medical School University of Patras Patras Greece

3. Department of Anatomy‐Histology‐Embryology, School of Medicine University of Patras Patras Greece

4. Department of Molecular Biology University of Geneva Geneva Switzerland

5. Stem Cell Engineering, Biotechnology Center, Center for Molecular and Cellular Bioengineering University of Technology Dresden Dresden Germany

6. Max Planck Institute of Molecular Cell Biology and Genetics Dresden Germany

7. International Institute of Anticancer Research Kapandriti Greece

8. Department of Histology and Embryology, School of Medicine National Kapodistrian University of Athens Athens Greece

9. Biomedical Research Foundation of the Academy of Athens Athens Greece

10. Faculty of Biology, Medicine and Health University of Manchester, Manchester Academic Health Science Centre Manchester UK

11. Institute of Molecular Biology (IMB) Mainz Germany

Funder

European Research Council

Publisher

Wiley

Subject

Pathology and Forensic Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/path.6017

Reference43 articles.

1. Replication Licensing Aberrations, Replication Stress, and Genomic Instability

2. A p53-Dependent Checkpoint Pathway Prevents Rereplication

3. Deregulated Overexpression of hCdt1 and hCdc6 Promotes Malignant Behavior

4. Cdt1 transgenic mice develop lymphoblastic lymphoma in the absence of p53

5. In Vivo DNA Re-replication Elicits Lethal Tissue Dysplasias

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