Technical note: Evaluation of the dose enhancement effect for a novel transmission‐type x‐ray tube using the Monte Carlo method-Reference-Cited by-同舟云学术

Technical note: Evaluation of the dose enhancement effect for a novel transmission‐type x‐ray tube using the Monte Carlo method

Published:2023-09 Issue:12 Volume:50 Page:8057-8062
ISSN:0094-2405
Container-title:Medical Physics
language:en
Short-container-title:Medical Physics

Author:

Lin Chin‐Hsiung¹²³,Wu Chin‐Hui⁴,Lai Yuan‐Chun⁵⁶,Chuang Ho‐Da¹²³,Hsiao Ching‐Yu¹²,Wu Ni‐Shan¹²,Tseng Shao‐Chun⁷,Feng Chen‐Ju¹²,Hsu Shih‐Ming¹²

Affiliation:

1. Medical Physics and Radiation Measurements Laboratory National Yang Ming Chiao Tung University Taipei Taiwan ROC

2. Department of Biomedical Imaging and Radiological Sciences National Yang Ming Chiao Tung University Taipei Taiwan ROC

3. Department of Medical Physics Koo Foundation Sun Yat‐Sen Cancer Center Taipei Taiwan ROC

4. Department of Medical Imaging and Radiological Sciences Tzu‐Chi University of Science and Technology Hualien Taiwan ROC

5. Department of Radiation Oncology Changhua Christian Hospital Changhua Taiwan ROC

6. Department of Medical Imaging and Radiological Sciences Central Taiwan University of Science and Technology Taichung Taiwan ROC

7. NanoRay Biotech Co., Ltd Taipei Taiwan ROC

Abstract

AbstractPurposeTransmission‐target x‐ray tubes generate more x‐rays than reflection thick‐target x‐ray tubes. A transmission x‐ray tube combined with radiosensitizers has a better radiation enhancement effect. This study investigated the feasibility of using a transmission x‐ray tube with radiosensitizers in clinical radiotherapy and its effect on radiation dose enhancement.MethodsThis study used MCNP6.2 to simulate the model of a transmission x‐ray tube and Co‐60 beam. The radiation enhancement effect of radiosensitizers was examined with iodine‐127 (I‐127), radioiodinated iododeoxyuridine (IUdR), and gold nanoparticles (GNPs).ResultsThe study results showed that the dose enhancement factor (DEF) of the transmission x‐ray tube with GNPs was 10.27, which was higher than that of I‐127 (6.46) and IUdR (3.08). The DEF of the Co‐60 beam with GNPs, I‐127, and IUdR was 1.23, 1.19, and 1.2, respectively. The Auger electron flux of the transmission x‐ray tube with GNPs was 1.19E+05 particles/cm2.ConclusionsThis study found that a transmission x‐ray tube with appropriate radiosensitizers could produce a high rate of Auger electrons to fulfill the radiation enhancement effect, and this procedure has the potential to become a radiotherapy modality.

Funder

National Science and Technology Council

Publisher

Wiley

Subject

General Medicine

Link

https://aapm.onlinelibrary.wiley.com/doi/pdf/10.1002/mp.16678

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