Heme Orientation of Cavity Mutant Hemoglobins (His F8 → Gly) in Either α or β Subunits: Circular Dichroism,1H NMR, and Resonance Raman Studies

Author:

Nagai Masako12,Nagai Yukifumi2,Aki Yayoi2,Sakurai Hiroshi2,Mizusawa Naoki1,Ogura Takashi3,Kitagawa Teizo3,Yamamoto Yasuhiko4,Nagatomo Shigenori4

Affiliation:

1. Research Center for Micro-Nano Technology; Hosei University; Koganei Tokyo Japan

2. Department of Health Sciences; Kanazawa University School of Medicine; Kanazawa Japan

3. Picobiology Institute, Graduate School of Life Science; University of Hyogo, RSC-UH Leading Program Center; Hyogo Japan

4. Department of Chemistry; University of Tsukuba; Tsukuba Ibaraki Japan

Funder

Grant-in-Aid from the Ministry of Education, Culture, Sports, Science, and Technology, Japan

Publisher

Wiley

Subject

Organic Chemistry,Spectroscopy,Drug Discovery,Pharmacology,Catalysis,Analytical Chemistry

Reference43 articles.

1. Changes of near-UV CD spectrum of human hemoglobin upon oxygen binding: A study of mutants at α42, α140, β145 tyrosine or β37 tryptophan;Jin;Biopolymers,2004

2. Changes of Near-UV Circular Dichroism Spectra of Human Hemoglobin upon the R→T Quaternary Structure Transition

3. Circular dichroism of hemoglobin and its subunits in the Soret region;Nagai;J Biol Chem,1969

4. Circular dichroism of hemoglobin in relation to the structure surrounding the heme;Sugita;J Biol Chem,1971

5. Oxygen equilibrium and circular dichroism of Hemoglobin-Rainier (α2β2145Tyr→Cys);Nagai;J Biol Chem,1972

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