Phase 1 dose-escalation study of mirvetuximab soravtansine (IMGN853), a folate receptor α-targeting antibody-drug conjugate, in patients with solid tumors

Author:

Moore Kathleen N.1ORCID,Borghaei Hossein2,O'Malley David M.3,Jeong Woondong4,Seward Shelly M.5,Bauer Todd M.6,Perez Raymond P.7,Matulonis Ursula A.8,Running Kelli L.9,Zhang Xiaoyan9,Ponte Jose F.9,Ruiz-Soto Rodrigo9,Birrer Michael J.10

Affiliation:

1. Department of Obstetrics and Gynecology; University of Oklahoma Health Sciences Center; Oklahoma City Oklahoma

2. Department of Hematology/Oncology; Fox Chase Cancer Center; Philadelphia Pennsylvania

3. Department of Obstetrics and Gynecology; The Ohio State University College of Medicine; Columbus Ohio

4. Cancer Therapy and Research Center; University of Texas Health Science Center; San Antonio Texas

5. Department of Obstetrics and Gynecology; Wayne State University; Detroit Michigan

6. Sarah Cannon Research Institute/Tennessee Oncology; PLLC; Nashville Tennessee

7. Division of Hematology/Oncology, University of Kansas; Fairway Kansas

8. Department of Medical Oncology; Dana Farber Cancer Institute; Boston Massachusetts

9. ImmunoGen, Inc.; Waltham Massachusetts

10. Gillette Center for Gynecologic Oncology; Massachusetts General Hospital; Boston Massachusetts

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference33 articles.

1. The relationship between high-dose treatment and combination chemotherapy: the concept of summation dose intensity;Frei;Clin Cancer Res.,1998

2. Targeted cancer therapy: conferring specificity to cytotoxic drugs;Chari;Acc Chem Res.,2008

3. Proteins: emerging carrier for delivery of cancer therapeutics;Yewale;Expert Opin Drug Deliv.,2013

4. Peptides, proteins and peptide/protein-polymer conjugates as drug delivery system;Mukherjee;Protein Pept Lett.,2014

5. Antibody-drug conjugates: an emerging concept in cancer therapy;Chari;Angewandte Chemie.,2014

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