<scp>DRD4</scp> gene polymorphism and impulse control disorder induced by dopamine agonists in Parkinson's disease-Reference-Cited by-同舟云学术

DRD4 gene polymorphism and impulse control disorder induced by dopamine agonists in Parkinson's disease

Published:2024-07 Issue:8 Volume:11 Page:2222-2229
ISSN:2328-9503
Container-title:Annals of Clinical and Translational Neurology
language:en
Short-container-title:Ann Clin Transl Neurol

Author:

Torres Viviana¹^ORCID,Pérez‐Montesino Jesica²,Fernández‐Santiago Rubén²^ORCID,Fernández Manel²,Camara Ana¹,Compta Yaroslau¹,Martí María‐José¹,Guerra Beltran Àlex²,Rios José³⁴,Valldeoriola Francesc¹^ORCID,Ezquerra Mario²

Affiliation:

1. Parkinson's Disease and Movement Disorders Unit, Neurology Service Institut de Neurociencies UBNeuro, Hospital Clínic Universitari de Barcelona Barcelona Catalonia Spain

2. Lab of Parkinson's disease and other Neurodegenerative Movement Disorders: Clinical and Experimental Research Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS) Barcelona 08036 Catalonia Spain

3. Department of Clinical Pharmacology, Hospital Clinic, and Medical Statistics Core Facility Institutd'InvestigacionsBiomèdiques August Pi ISunyer (IDIBAPS) Barcelona Catalonia Spain

4. Biostatistics Unit, School of Medicine UniversitatAutònoma de Barcelona Barcelona Catalonia Spain

Abstract

AbstractImpulse control disorders and their consequences display variability among individuals, indicating potential involvement of environmental and genetic factors. In this retrospective study, we analyzed a cohort of Parkinson's disease patients treated with dopamine agonists and investigated the influence of the dopamine D4 receptor gene polymorphism, DRD4 7R+, which is linked to psychiatric disorders, impulsive traits, and addictive behaviors. We found that DRD4 7R+ is a significant genetic risk factor associated with the severity of ICD.

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/acn3.52111

Reference19 articles.

1. Frequency of levodopa‐related dyskinesias and motor fluctuations as estimated from the cumulative literature

2. Pramipexole vs Levodopa as Initial Treatment for Parkinson Disease

3. Impulse Control Disorders in Parkinson Disease

4. Impulse control disorders and related behaviors in Parkinson's disease

5. Genetic prediction of impulse control disorders in Parkinson's disease