Affiliation:
1. Department of Radiology, The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China
2. Department of Radiology Southwest Hospital, Army Medical University (Third Military Medical University) Chongqing China
Abstract
Cerebral small vessel disease is a major contributor to brain disorders in older adults. It is associated with a much higher risk of stroke and dementia. Due to a lack of clinical and fluid biomarkers, diagnosing and grading small vessel disease are highly dependent on magnetic resonance imaging. In the past, researchers mostly used brain parenchymal imaging markers to represent small vessel damage, but the relationships between these surrogate markers and small vessel pathologies are complex. Recent progress in high‐resolution magnetic resonance imaging methods, including time‐of‐flight MR angiography, phase‐contrast MR angiography, black blood vessel wall imaging, susceptibility‐weighted imaging, and contrast‐enhanced methods, allow for direct visualization of cerebral small vessel structures. They could be powerful tools for understanding aging‐related small vessel degeneration and improving disease diagnosis and treatment. This article will review progress in these imaging techniques and their application in aging and disease studies. Some challenges and future directions are also discussed.Evidence Level4.Technical Efficacy3.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Zhejiang Province
China Postdoctoral Science Foundation
Zhejiang Provincial Postdoctoral Science Foundation
Subject
Radiology, Nuclear Medicine and imaging
Cited by
2 articles.
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