Sociodemographic characteristics associated with cervical cancer screening participation by send‐to‐all and opt‐in HPV self‐sampling: Who benefits? Results from a randomized controlled trial among long‐term non‐attending women in Norway

Author:

Hansen Bo T.12ORCID,Nygård Mari2ORCID,Castle Phil E.34,Burger Emily A.56ORCID,Aasbø Gunvor27ORCID

Affiliation:

1. Department of Infection Control and Vaccine Norwegian Institute of Public Health Oslo Norway

2. Department of Research, Cancer Registry of Norway Norwegian Institute of Public Health Oslo Norway

3. Division of Cancer Prevention, National Cancer Institute National Institutes of Health Rockville Maryland USA

4. Division of Cancer Epidemiology and Genetics, National Cancer Institute National Institutes of Health Rockville Maryland USA

5. Department of Health Management and Health Economics University of Oslo Oslo Norway

6. Harvard Center for Health Decision Science Harvard T.H. Chan School of Public Health Boston Massachusetts USA

7. Department of Interdisciplinary Health Science University of Oslo Oslo Norway

Abstract

AbstractWith the objective to investigate associations between sociodemographic characteristics and participation in interventions designed to increase participation in cervical cancer screening among under‐screened women, we randomized a random sample of 6000 women in Norway aged 35–69 years who had not attended cervical screening for ≥10 years to receive either (i) a reminder to attend regular screening (control), (ii) an offer to order a self‐sampling kit (opt‐in), or (iii) a self‐sampling kit unsolicited (send‐to‐all). We analyzed how sociodemographic characteristics were associated with screening participation within and between screening arms. In the send‐to‐all arm, increased screening participation ranged from 17.1% (95% confidence interval [95% CI] = 10.3% to 23.8%) to 30.0% (95% CI = 21.5% to 38.6%) between sociodemographic groups. In the opt‐in arm, we observed smaller, and at times, non‐significant increases within the range 0.7% (95% CI = −5.8% to 7.3%) to 19.1% (95% CI = 11.6% to 26.7%). In send‐to‐all versus control comparisons, there was greater increase in participation for women in the workforce versus not (6.1%, 95% CI = 1.6% to 10.6%), with higher versus lower income (7.6%, 95% CI = 2.2% to 13.1%), and with university versus primary education (8.5%, 95% CI = 2.4% to 14.6%). In opt‐in versus control comparisons, there was greater increase in participation for women in the workforce versus not (4.6%, 95% CI = 0.7% to 8.5%), with higher versus lower income (6.3%, 95% CI = 1.5% to 11.1%), but lower increase for Eastern European versus Norwegian background (−12.7%, 95% CI = −19.7% to −5.7%). Self‐sampling increased cervical screening participation across all sociodemographic levels, but inequalities in participation should be considered when introducing self‐sampling, especially with the goal to reach long‐term non‐attending women.

Funder

Kreftforeningen

Publisher

Wiley

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