LDLR dysfunction induces LDL accumulation and promotes pulmonary fibrosis

Author:

Shi Xiangguang1,Chen Yahui2,Liu Qingmei1,Mei Xueqian1,Liu Jing23,Tang Yulong2,Luo Ruoyu2,Sun Dayan2,Ma Yanyun45,Wu Wenyu1,Tu Wenzhen6,Zhao Yinhuan6,Xu Weihong7,Ke Yuehai8,Jiang Shuai12,Huang Yan1,Zhang Rui15,Wang Lei6,Chen Yuanyuan6,Xia Jingjing2,Pu Weilin2,Zhu Honglin910,Zuo Xiaoxia10,Li Yisha10,Xu Jinhua1,Gao Fei11,Wei Dong11,Chen Jingyu11,Yin Wenguang12,Wang Qingwen13,Dai Huaping14,Yang Libing1415,Guo Gang16,Cui Jimin16,Song Nana17,Zou Hejian318,Zhao Shimin19,Distler Jörg H.W.9,Jin Li220,Wang Jiucun121820ORCID

Affiliation:

1. Department of Dermatology, Huashan Hospital and State Key Laboratory of Genetic Engineering, School of Life Sciences Fudan University Shanghai P. R. China

2. Human Phenome Institute and Collaborative Innovation Center for Genetics and Development Fudan University Shanghai P. R. China

3. Division of Rheumatology Huashan hospital, Fudan University Shanghai P. R. China

4. MOE Key Laboratory of Contemporary Anthropology, Department of Anthropology and Human Genetics, School of Life Sciences Fudan University Shanghai P. R. China

5. Institute for Six‐sector Economy Fudan University Shanghai P. R. China

6. Division of Rheumatology Shanghai TCM‐Integrated Hospital Shanghai P. R. China

7. The Clinical Laboratory of Tongren Hosipital Shanghai Jiaotong University Shanghai P. R. China

8. Department of Pathology and Pathophysiology Zhejiang University School of Medicine Hangzhou Zhejiang Province P. R. China

9. Department of Internal Medicine 3 and Institute for Clinical Immunology University of Erlangen Nuremberg Germany

10. Department of Rheumatology, Xiangya Hospital Central South University Changsha Hunan Province P. R. China

11. Wuxi Lung Transplant Center Wuxi People's Hospital affiliated to Nanjing Medical University Wuxi P. R. China

12. State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health The First Affiliated Hospital of Guangzhou Medical University Guangzhou Guangdong P. R. China

13. Rheumatology and Immunology Department Peking University Shenzhen Hospital Shenzhen P. R. China

14. Department of Pulmonary and Critical Care Medicine, China‐Japan Friendship Hospital; National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine Chinese Academy of Medical Science Beijing P. R. China

15. School of Medicine Tsinghua University Beijing P. R. China

16. Department of Rheumatology and Immunology Yiling Hospital Affiliated to Hebei Medical University Shijiazhuang Hebei Province P. R. China

17. Department of Nephrology, Zhongshan Hospital, Fudan University Fudan Zhangjiang Institute Shanghai P. R. China

18. Institute of Rheumatology, Immunology and Allergy Fudan University Shanghai P. R. China

19. Institute of Metabolism and Integrative Biology Fudan University Shanghai P. R. China

20. Research Unit of Dissecting the Population Genetics and Developing New Technologies for Treatment and Prevention of Skin Phenotypes and Dermatological Diseases (2019RU058) Chinese Academy of Medical Sciences Shanghai P. R. China

Funder

National Natural Science Foundation of China

Chinese Academy of Medical Sciences

Publisher

Wiley

Subject

Molecular Medicine,Medicine (miscellaneous)

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