Pharmacodynamic comparison of LY3023703, a novel microsomal prostaglandin e synthase 1 inhibitor, with celecoxib

Author:

Jin Y1,Smith CL2,Hu L1,Campanale KM1,Stoltz R3,Huffman LG1,McNearney TA1,Yang XY1,Ackermann BL1,Dean R1,Regev A1,Landschulz W1

Affiliation:

1. Eli Lilly and Company; Indianapolis Indiana USA

2. Eli Lilly and Company; Lilly UK; Windlesham Surrey UK

3. Covance Clinical Research Unit; Evansville Indiana USA

Funder

Eli Lilly and Company, Indianapolis, IN

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference20 articles.

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3. Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: the human pharmacology of a selective inhibitor of COX-2;McAdam;Proc. Natl. Acad. Sci. U. S. A.,2005

4. Effects of specific inhibition of cyclooxygenase-2 on sodium balance, hemodynamics, and vasoactive eicosanoids;Catella-Lawson;J. Pharmacol. Exp. Ther.,1999

5. Targeted deletions of cyclooxygenase-2 and atherogenesis in mice;Hui;Circulation,2010

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