Identification and functional analysis of a novel G310D variant in the insulin-like growth factor 1 receptor (IGF1R ) gene associated with type 2 diabetes in American Indians

Author:

Muller Yunhua L.1ORCID,Skelton Graham1,Piaggi Paolo1ORCID,Chen Peng1,Nair Anup1,Kobes Sayuko1,Hsueh Wen-Chi1,Knowler William C.1,Hanson Robert L.1,Baier Leslie J.1,Bogardus Clifton1

Affiliation:

1. Phoenix Epidemiology and Clinical Research Branch; National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health; Phoenix AZ USA

Publisher

Wiley

Subject

Endocrinology,Endocrinology, Diabetes and Metabolism,Internal Medicine

Reference20 articles.

1. Diabetes mellitus in the Pima Indians: incidence, risk factors and pathogenesis;Knowler;Diabetes Metab Rev,1990

2. Role of established type 2 diabetes-susceptibility genetic variants in a high prevalence American Indian population;Hanson;Diabetes,2015

3. Strong parent-of-origin effects in the association of KCNQ1 variants with type 2 diabetes in American Indians;Hanson;Diabetes,2013

4. Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r);Liu;Cell,1993

5. Mouse models created to study the pathophysiology of type 2 diabetes;LeRoith;Int J Biochem Cell Biol,2006

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