Successful treatment with nivolumab in a patient with unresectable oral squamous cell carcinoma following ineffective chemoradiotherapy-Reference-Cited by-同舟云学术

Successful treatment with nivolumab in a patient with unresectable oral squamous cell carcinoma following ineffective chemoradiotherapy

Published:2023-11-28 Issue:12 Volume:11 Page:
ISSN:2050-0904
Container-title:Clinical Case Reports
language:en
Short-container-title:Clinical Case Reports

Author:

Sekido Katsuhisa¹²^ORCID,Imaue Shuichi¹,Tachinami Hidetake¹^ORCID,Tomihara Kei³^ORCID,Naruto Norihito⁴,Yamagishi Kentaro⁴,Ikeda Atsushi¹,Fujiwara Kumiko⁵^ORCID,Noguchi Makoto¹

Affiliation:

1. Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Academic Assembly University of Toyama 2630 Sugitani Toyama City Japan

2. Department of Oral and Maxillofacial Surgery Toyama Red Cross Hospital Toyama City Japan

3. Divisions of Oral and Maxillofacial Surgery Niigata University Graduate School of Medical and Dental Sciences Niigata Japan

4. Department of Radiology, Faculty of Medicine, Academic Assembly University of Toyama Toyama City Japan

5. Department of Dentistry and Oral Surgery, Division of Medicine for Function and Morphology of Sensory Organs, Faculty of Medicine Osaka Medical and Pharmaceutical University Takatsuki Japan

Abstract

Key clinical messageNivolumab has been clinically successful in prolonging the overall survival of patients with recurrent and metastatic head and neck cancer, complete remission is rare. Synergistic combinations of immunotherapy and conventional cancer treatments, such as radiotherapy or chemotherapy, are likely to be the most viable strategies for improving patient responses.AbstractImmune checkpoint inhibitors have revolutionized recurrent, metastatic oral cancer treatment; however complete remission in advanced stages is unusual. We present a case of complete remission of advanced oral squamous cell carcinoma for >4 years in a 64‐year‐old Japanese woman, that responded poorly to chemoradiotherapy but well to subsequent nivolumab treatment.

Publisher

Wiley

Subject

General Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ccr3.8219

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