Secondary mutations in BRCA2 associated with clinical resistance to a PARP inhibitor
Author:
Affiliation:
1. Breakthrough Breast Cancer Research Centre; Institute of Cancer Research; London UK
2. Royal Marsden NHS Foundation Trust and Institute of Cancer Research; Sutton Surrey UK
Publisher
Wiley
Subject
Pathology and Forensic Medicine
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1002/path.4140/fullpdf
Reference18 articles.
1. BRCA1 and BRCA2: different roles in a common pathway of genome protection;Roy;Nat Rev Cancer,2012
2. Germline mutations in RAD51D confer susceptibility to ovarian cancer;Loveday;Nat Genet,2011
3. Stabilization of RAD51 nucleoprotein filaments by the C-terminal region of BRCA2;Esashi;Nat Struct Mol Biol,2007
4. The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability;Gudmundsdottir;Oncogene,2006
5. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy;Farmer;Nature,2005
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