Affiliation:
1. National Laboratory of Solid State Microstructures Jiangsu Key Laboratory of Artificial Functional Materials Chemistry and Biomedicine Innovation Center Collaborative Innovation Center of Advanced Microstructures College of Engineering and Applied Sciences Nanjing University Nanjing 210023 China
2. Key Laboratory of Inflammation and Immunoregulation School of Medicine and Holistic Integrative Medicine Nanjing University of Chinese Medicine Nanjing 210023 China
3. Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China
Abstract
AbstractElectrical stimulation is a promising strategy for treating neural diseases. However, current energy suppliers cannot provide effective power for in situ electrical stimulation. Here, an implantable tubular zinc–oxygen battery is reported as the power source for in situ electrical stimulation during the neural repair. The battery exhibited a high volumetric energy density of 231.4 mWh cm−3 based on the entire anode and cathode in vivo. Due to its superior electrochemical properties and biosafety, the battery can be directly wrapped around the nerve to provide in situ electrical stimulation with a minimal size of 0.86 mm3. The cell and animal experiments demonstrated that the zinc–oxygen battery‐based nerve tissue engineering conduit effectively promoted regeneration of the injured long‐segment sciatic nerve, proving its promising applications for powering implantable neural electronics in the future.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Jiangsu Province
China Postdoctoral Science Foundation
National Postdoctoral Program for Innovative Talents
Jiangsu Postdoctoral Research Foundation
Subject
Mechanical Engineering,Mechanics of Materials,General Materials Science
Cited by
25 articles.
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