Affiliation:
1. State Key Laboratory of Organic‐Inorganic Composites Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology Beijing 100029 China
2. MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027 China
3. Peking University Third Hospital Beijing 100191 China
4. Institute of Sports Medicine Beijing Key Laboratory of Sports Injuries Peking University Third Hospital Beijing 100191 China
Abstract
AbstractThe repair of hierarchical osteochondral defect requires sophisticated gradient reestablishment; however, few strategies for continuous gradient casting consider the relevance to clinical practice regarding cell adaptability, multiple gradient elements, and precise gradient mirroring native tissue. Here, a hydrogel with continuous gradients in nano‐hydroxyapatite (HA) content, mechanical, and magnetism is developed using synthesized superparamagnetic HA nanorods (MagHA) that easily respond to a brief magnetic field. To precisely reconstruct osteochondral tissue, the optimized gradient mode is calculated according to magnetic resonance imaging (MRI) of healthy rabbit knees. Then, MagHA are patterned to form continuous biophysical and biochemical gradients, consequently generating incremental HA, mechanical, and electromagnetic cues under an external magnetic stimulus. To make such depth‐dependent biocues work, an adaptable hydrogel is developed to facilitate cell infiltration. Furthermore, this approach is applied in rabbit full‐thickness osteochondral defects equipped with a local magnetic field. Surprisingly, this multileveled gradient composite hydrogel repairs osteochondral unit in a perfect heterogeneous feature, which mimics the gradual cartilage‐to‐subchondral transition. Collectively, this is the first study that combines an adaptable hydrogel with magneto‐driven MagHA gradients to achieve promising outcomes in osteochondral regeneration.
Funder
National Natural Science Foundation of China
Fundamental Research Funds for the Central Universities
Natural Science Foundation of Beijing Municipality
Subject
Mechanical Engineering,Mechanics of Materials,General Materials Science
Cited by
34 articles.
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