A phase 2 study of the efficacy and biomarker on the combination of transarterial chemoembolization and axitinib in the treatment of inoperable hepatocellular carcinoma

Author:

Chan Stephen L.123ORCID,Yeo Winnie12,Mo Frankie12,Chan Anthony W.H.14ORCID,Koh Jane2,Li Leung2,Hui Edwin P.12,Chong Charing C.N.5,Lai Paul B.S5,Mok Tony S.K.12,Yu Simon C.H.6

Affiliation:

1. State Key Laboratory of Oncology in South China; Hong Kong

2. Sir YK Pao Center for Cancer; Department of Clinical Oncology, Hong Kong Cancer Institute and Prince of Wales Hospital, The Chinese University of Hong Kong; Hong Kong

3. Institute of Digestive Disease; The Chinese University of Hong Kong; Hong Kong

4. Department of Anatomical and Cellular Pathology; The Chinese University of Hong Kong; Hong Kong

5. Department of Surgery; The Chinese University of Hong Kong; Hong Kong

6. Department of Imaging and Interventional Radiology; The Chinese University of Hong Kong; Hong Kong

Funder

Pfizer

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference31 articles.

1. The potential role of hypoxia inducible factor 1alpha in tumor progression after hypoxia and chemotherapy in hepatocellular carcinoma;Yang;Cancer Res.,2004

2. Expression of plasma vascular endothelial growth factor in patients with hepatocellular carcinoma and effect of transcatheter arterial chemoembolization therapy on plasma vascular endothelial growth factor level;Li;World J Gastroenterol.,2004

3. TACE and sorafenib: a good marriage?;Abou-Alfa;J Clin Oncol.,2011

4. Sorafenib or placebo plus TACE with doxorubicin-eluting beads for intermediate stage HCC: the SPACE trial;Lencioni;J Hepatol.,2016

5. TACE 2: a randomized placebo-controlled, double-blinded, phase III trial evaluating sorafenib in combination with transarterial chemoembolisation (TACE) in patients with unresectable hepatocellular carcinoma (HCC) [abstract];Meyer;J Clin Oncol.,2016

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