Identification of higenamine as a novel α1 -adrenergic receptor antagonist

Author:

Zhang Nana1,Qu Kai1,Wang Minjie12,Yin Qian3,Wang Wenjing3,Xue Lixiang4,Fu Haian5,Zhu Haibo1ORCID,Li Zijian3

Affiliation:

1. State Key Laboratory for Bioactive Substances and Functions of Natural Medicines; Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study; Institute of Materia Medica; Chinese Academy of Medical Sciences and Peking Union Medical College; Beijing China

2. School of Basic Medical Sciences; Inner Mongolia Medical University, Jinshan Development District; Hohhot PR China

3. Department of Cardiology and Institute of Vascular Medicine; Peking University Third Hospital; Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health; Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education; Beijing Key Laboratory of Cardiovascular Receptors Research; Beijing China

4. Medical Research Center; Peking University Third Hospital; Beijing China

5. Department of Pharmacology; Emory University School of Medicine; Atlanta Georgia

Funder

National Natural Science Foundation of China

Natural Science Foundation of Beijing Municipality

CAMS Innovation Fund for Medical Sciences

Publisher

Wiley

Subject

Pharmacology

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