Metabolic analysis of the asparagine and glutamine dynamics in an industrial Chinese hamster ovary fed‐batch process-Reference-Cited by-同舟云学术

Metabolic analysis of the asparagine and glutamine dynamics in an industrial Chinese hamster ovary fed‐batch process

Published:2022-01-06 Issue:3 Volume:119 Page:807-819
ISSN:0006-3592
Container-title:Biotechnology and Bioengineering
language:en
Short-container-title:Biotech & Bioengineering

Author:

Kirsch Brian J.¹,Bennun Sandra V.²,Mendez Adam¹,Johnson Amy S.²,Wang Hongxia³,Qiu Haibo³,Li Ning³,Lawrence Shawn M.²,Bak Hanne²,Betenbaugh Michael J.¹^ORCID

Affiliation:

1. Department of Chemical and Biomolecular Engineering Johns Hopkins University Baltimore Maryland USA

2. Regeneron Pharmaceuticals Inc. Preclinical Manufacturing and Process Development Tarrytown New York USA

3. Regeneron Pharmaceuticals Inc. Analytical Chemistry Group Tarrytown New York USA

Publisher

Wiley

Subject

Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/bit.27993

Reference68 articles.

1. Towards dynamic metabolic flux analysis in CHO cell cultures

2. Evidence for transketolase-like TKTL1 flux in CHO cells based on parallel labeling experiments and 13 C-metabolic flux analysis

3. Redox control of glutamine utilization in cancer

4. Apoptosis in cell culture

5. Considerations on the lactate consumption by CHO cells in the presence of galactose

Cited by 15 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Data-driven parameterization and development of mechanistic cell cultivation models in monoclonal antibody production processes: Shifts in cell metabolic behavior;Computers & Chemical Engineering;2024-12

2. Ala-Cys-Cys-Ala dipeptide dimer alleviates problematic cysteine and cystine levels in media formulations and enhances CHO cell growth and metabolism;Metabolic Engineering;2024-09

3. Flux balance analysis and peptide mapping elucidate the impact of bioreactor pH on Chinese Hamster Ovary (CHO) cell metabolism and N-linked glycosylation in the Fab and Fc regions of the produced IgG;2024-08-02

4. Elevated nutrient availability enhances chondrocyte metabolism and biosynthesis in tissue-engineered cartilage;Osteoarthritis and Cartilage;2024-07

5. Metabolomic characterization of monoclonal antibody‐producing Chinese hamster lung (CHL)‐YN cells in glucose‐controlled serum‐free fed‐batch operation;Biotechnology and Bioengineering;2024-06-22