Affiliation:
1. Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University Wenzhou Medical University Wenzhou Zhejiang China
2. Department of Clinical Medicine Chinese Medicine Hospital of Pingyang Wenzhou Zhejiang China
3. Department of Pediatrics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou Medical University Wenzhou Zhejiang China
Abstract
AbstractWith the progress in neonatal intensive care, there has been an increase in the survival rates of premature infants. However, this has also led to an increased incidence of neonatal hyperoxia lung injury and bronchopulmonary dysplasia (BPD), whose pathogenesis is believed to be influenced by various prenatal and postnatal factors, although the exact mechanisms remain unclear. Recent studies suggest that multiple mechanisms might be involved in neonatal hyperoxic lung injury and BPD, with sex also possibly playing an important role, and numerous drugs have been proposed and shown promise for improving the treatment outcomes of hyperoxic lung injury. Therefore, this paper aims to analyze and summarize sex differences in neonatal hyperoxic lung injury, potential pathogenesis and treatment progress to provide new ideas for basic and clinical research in this field.