UK Medical Cannabis Registry: Assessment of clinical outcomes in patients with insomnia

Author:

Vivek Kavyesh1ORCID,Karagozlu Zekiye1,Erridge Simon12ORCID,Holvey Carl2,Coomber Ross23,Rucker James J.245,Weatherall Mark W.26,Sodergren Mikael H12

Affiliation:

1. Imperial College Medical Cannabis Research Group, Department of Surgery and Cancer Imperial College London London UK

2. Department of Medicine Curaleaf Clinic London UK

3. Department of Trauma and Orthopaedics St. George's Hospital NHS Trust London UK

4. Department of Psychological Medicine Kings College London London UK

5. National and Specialist Tertiary Referrals Affective Disorders Service South London & Maudsley NHS Foundation Trust London UK

6. Department of Neurology Buckinghamshire Healthcare NHS Trust Amersham UK

Abstract

AbstractIntroductionThe primary aim of this study was to assess changes in sleep‐specific health‐related quality of life (HRQoL) for those prescribed cannabis‐based medicinal products (CBMPs) for insomnia.MethodsA case series of UK patients with insomnia was analyzed. Primary outcomes were changes in the Single‐Item Sleep‐Quality Scale (SQS), Generalized Anxiety Disorder‐7 (GAD‐7), and EQ‐5D‐5L at up to 6 months from baseline. Statistical significance was identified as a p value < .050.Results61 patients were included in the analysis. There was an improvement in the SQS from baseline at 1, 3, and 6 months (p < .001). There were also improvements in the EQ‐5D‐5L Index value and GAD‐7 at 1, 3, and 6 months (p < .050). There were 28 (45.9%) adverse events recorded by 8 patients (13.1%). There were no life‐threatening/disabling adverse events.ConclusionPatients with insomnia experienced an improvement in sleep quality following the initiation of CBMPs in this medium‐term analysis. Fewer than 15% of participants reported one or more adverse events. However, due to the limitations of the study design, further investigation is required before definitive conclusions can be drawn on the efficacy of CBMPs in treating insomnia.

Publisher

Wiley

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3