A novel and potent dihydroorotate dehydrogenase inhibitor suppresses the proliferation of colorectal cancer by inducing mitochondrial dysfunction and DNA damage-Reference-Cited by-同舟云学术

A novel and potent dihydroorotate dehydrogenase inhibitor suppresses the proliferation of colorectal cancer by inducing mitochondrial dysfunction and DNA damage

Published:2022-06 Issue:1 Volume:1 Page:
ISSN:2769-6448
Container-title:MedComm – Oncology
language:en
Short-container-title:MedComm – Oncology

Author:

Yang Xiaowei¹,Li Chungen²,Gou Kun²,Liu Xiaocong²,Zhou Yue²,Zou Jiao²,Chen Qiang²,Luo Youfu²^ORCID,Zhao Yinglan¹²^ORCID

Affiliation:

1. Department of Pharmacology, Key Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant‐Sourced Drug, West China School of Pharmacy, Sichuan Research Center for Drug Precision Industrial Technology Sichuan University Chengdu Sichuan China

2. State Key Laboratory of Biotherapy and Cancer Center, West China Hospital West China Medical Chengdu Sichuan China

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/mog2.6

Reference51 articles.

1. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries

2. Colorectal cancer

3. Molecular Targeted Drugs and Treatment of Colorectal Cancer: Recent Progress and Future Perspectives

4. Regional mapping of the gene encoding dihydroorotate dehydrogenase, an enzyme involved in UMP synthesis, electron transport, and superoxide generation, to human chromosome region 16q22

5. Revisiting the role of dihydroorotate dehydrogenase as a therapeutic target for cancer

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