Mendelian randomisation implicates hyperlipidaemia as a risk factor for colorectal cancer

Author:

Rodriguez‐Broadbent Henry1,Law Philip J.1ORCID,Sud Amit1,Palin Kimmo23,Tuupanen Sari23,Gylfe Alexandra23,Hänninen Ulrika A.23,Cajuso Tatiana23,Tanskanen Tomas23,Kondelin Johanna23,Kaasinen Eevi23,Sarin Antti‐Pekka4,Ripatti Samuli456,Eriksson Johan G.789,Rissanen Harri7,Knekt Paul7,Pukkala Eero1011,Jousilahti Pekka7,Salomaa Veikko7,Palotie Aarno4121314,Renkonen‐Sinisalo Laura15,Lepistö Anna15,Böhm Jan16,Mecklin Jukka‐Pekka17,Al‐Tassan Nada A.18,Palles Claire19,Martin Lynn19,Barclay Ella19,Farrington Susan M.20,Timofeeva Maria N.20,Meyer Brian F.18,Wakil Salma M.18,Campbell Harry21,Smith Christopher G.22,Idziaszczyk Shelley22,Maughan Timothy S.23,Kaplan Richard24,Kerr Rachel25,Kerr David26,Passarelli Michael N.27,Figueiredo Jane C.2829,Buchanan Daniel D.3031ORCID,Win Aung K.31ORCID,Hopper John L.31,Jenkins Mark A.31,Lindor Noralane M.32,Newcomb Polly A.33,Gallinger Steven34,Conti David35,Schumacher Fred35,Casey Graham36,Aaltonen Lauri A.23,Cheadle Jeremy P.22,Tomlinson Ian P.19,Dunlop Malcolm G.20,Houlston Richard S.1

Affiliation:

1. Division of Genetics and EpidemiologyThe Institute of Cancer ResearchLondon United Kingdom

2. Genome‐Scale Biology Research Program, Research Programs Unit, University of HelsinkiHelsinki Finland

3. Department of Medical and Clinical Genetics, MedicumUniversity of HelsinkiHelsinki Finland

4. Institute for Molecular Medicine Finland (FIMM), University of HelsinkiHelsinki Finland

5. Wellcome Trust Sanger Institute, Wellcome Trust Genome CampusHinxton Cambridge United Kingdom

6. Department of Public HealthUniversity of HelsinkiHelsinki Finland

7. National Institute for Health and WelfareHelsinki Finland

8. Folkhälsan Research CentreHelsinki Finland

9. Unit of General Practice and Primary Health CareUniversity of Helsinki and Helsinki University HospitalHelsinki Finland

10. Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer ResearchHelsinki Finland

11. Faculty of Social SciencesUniversity of TampereTampere Finland

12. Analytic and Translational Genetics Unit, Department of MedicineMassachusetts General HospitalBoston MA

13. Program in Medical and Population GeneticsThe Broad Institute of MIT and HarvardCambridge MA

14. Department of NeurologyMassachusetts General HospitalBoston MA

15. Department of SurgeryAbdominal Center, Helsinki University HospitalHelsinki Finland

16. Department of PathologyCentral Finland Central HospitalJyväskylä Finland

17. Department of SurgeryJyväskylä Central Hospital, University of Eastern FinlandJyväskylä Finland

18. Department of GeneticsKing Faisal Specialist Hospital and Research CenterRiyadh Saudi Arabia

19. Wellcome Trust Centre for Human Genetics and NIHR Comprehensive Biomedical Research CentreOxford United Kingdom

20. Colon Cancer Genetics Group, University of Edinburgh and MRC Human Genetics Unit, Western General HospitalEdinburgh United Kingdom

21. Centre for Population Health Sciences, University of EdinburghEdinburgh United Kingdom

22. Division of Cancer and Genetics, School of MedicineCardiff UniversityCardiff United Kingdom

23. CRUK/MRC Oxford Institute for Radiation Oncology, University of OxfordOxford United Kingdom

24. MRC Clinical Trials Unit, Aviation HouseLondon United Kingdom

25. Department of Oncology, Oxford Cancer CentreUniversity of Oxford, Churchill HospitalOxford United Kingdom

26. Nuffield Department of Clinical Laboratory SciencesUniversity of Oxford, John Radcliffe HospitalOxford United Kingdom

27. Department of Epidemiology, Geisel School of Medicine at DartmouthDartmouth‐Hitchcock Medical Center Lebanon NH

28. Samuel Oschin Comprehensive Cancer Center, Cedars‐Sinai Medical CenterLos Angeles CA

29. Keck School of MedicineUniversity of Southern CaliforniaLos Angeles CA

30. Department of Pathology, Colorectal Oncogenomics Group, Genetic Epidemiology LaboratoryThe University of MelbourneVictoria Australia

31. Centre for Epidemiology and BiostatisticsThe University of MelbourneVictoria Australia

32. Department of Health Sciences ResearchMayo ClinicScottsdale AZ

33. Cancer Prevention Program, Fred Hutchinson Cancer Research CenterSeattle WA

34. Lunenfeld‐Tanenbaum Research Institute, Mount Sinai HospitalToronto ON Canada

35. Department of Preventive MedicineUniversity of Southern CaliforniaLos Angeles CA

36. Center for Public Health Genomics, University of VirginiaCharlottesville VA

Funder

Wellcome Trust

Cancer Research UK

Academy of Finland

European Research Council

National Cancer Institute

California Department of Public Health

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference35 articles.

1. Cancer incidence in five continents;Forman D;IARC Sci Publ,2014

2. Cancer Research UK. vol. 2016.2016. Available at:http://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/bowel-cancer/survival. Accessed October 2016.

3. Cochrane Systematic Review of Colorectal Cancer Screening Using the Fecal Occult Blood Test (Hemoccult): An Update

4. Long-Term Mortality after Screening for Colorectal Cancer

5. Dyslipidemia and colorectal cancer risk: a meta-analysis of prospective studies

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