Visualizing the effects of lactate dehydrogenase (LDH) inhibition and LDH‐A genetic ablation in breast and lung cancer with hyperpolarized pyruvate NMR-Reference-Cited by-同舟云学术

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Visualizing the effects of lactate dehydrogenase (LDH) inhibition and LDH‐A genetic ablation in breast and lung cancer with hyperpolarized pyruvate NMR

Published:2021-06-04 Issue: Volume: Page:
ISSN:0952-3480
Container-title:NMR in Biomedicine
language:en
Short-container-title:NMR in Biomedicine

Author:

Varma Gopal¹^ORCID,Seth Pankaj²,Coutinho de Souza Patricia¹,Callahan Cody¹,Pinto Jocelin³,Vaidya Manushka¹³,Sonzogni Olmo³^ORCID,Sukhatme Vikas²⁴,Wulf Gerburg M.³,Grant Aaron K.¹

Affiliation:

1. Department of Radiology Beth Israel Deaconess Medical Center, Harvard Medical School Boston Massachusetts

2. Department of Medicine Harvard Medical School Boston Massachusetts

3. Department of Hematology and Oncology, Beth Israel Deaconess Medical Center Harvard Medical School Boston Massachusetts

4. Department of Medicine Emory University School of Medicine Atlanta Georgia

Funder

Breast Cancer Research Foundation

National Institutes of Health

Breast Cancer Alliance

Publisher

Wiley

Subject

Spectroscopy,Radiology Nuclear Medicine and imaging,Molecular Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/nbm.4560

Reference28 articles.

1. On respiratory impairment in cancer cells;Warburg O;Science,1956

2. Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression;Le A;Proc Natl Acad Sci U S A,2010

3. Reactive oxygen species (ROS) are a key determinant of cancer's metabolic phenotype;Rodic S;Int J Cancer,2018

4. Why do cancers have high aerobic glycolysis?;Gatenby RA;Nat Rev Cancer,2004

5. Tumor‐derived lactate and myeloid‐derived suppressor cells: Linking metabolism to cancer immunology;Husain Z;OncoImmunology,2013

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