1. Department of Gastroenterology, Rheumatology and Clinical Immunology; Sapporo Medical University; Sapporo Japan
2. Sapporo Shirakaba-Dai Hospital; Sapporo Japan
3. Medical Genome Sciences, Research Institute of Frontier Medicine; Sapporo Medical University; Sapporo Japan
4. Division of Gastroenterology and Hepatology, Department of Internal Medicine; St. Marianna University School of Medicine; Kawasaki Japan
5. James Cancer Center; The Ohio State University Medical Center; Columbus Ohio
6. The Institute of Medical Science Hospital; The University of Tokyo; Tokyo Japan