The effect of forced expression of mutatedK-RASgene on gastrointestinal cancer cell lines and the IGF-1R targeting therapy

Author:

Matsunaga Yasutaka1,Adachi Yasushi12,Sasaki Yasushi3,Koide Hideyuki1,Motoya Masayo1,Nosho Katsuhiko1,Takagi Hideyasu1,Yamamoto Hiroyuki4,Sasaki Shigeru1,Arimura Yoshiaki1,Tokino Takashi3,Carbone David P.5,Imai Kohzoh6,Shinomura Yasuhisa1

Affiliation:

1. Department of Gastroenterology, Rheumatology and Clinical Immunology; Sapporo Medical University; Sapporo Japan

2. Sapporo Shirakaba-Dai Hospital; Sapporo Japan

3. Medical Genome Sciences, Research Institute of Frontier Medicine; Sapporo Medical University; Sapporo Japan

4. Division of Gastroenterology and Hepatology, Department of Internal Medicine; St. Marianna University School of Medicine; Kawasaki Japan

5. James Cancer Center; The Ohio State University Medical Center; Columbus Ohio

6. The Institute of Medical Science Hospital; The University of Tokyo; Tokyo Japan

Funder

Ministry of Health, Labour and Welfare

Ono Cancer Research Fund

Japanese Society of Strategies for Cancer Research and Therapy

Publisher

Wiley

Subject

Cancer Research,Molecular Biology

Reference51 articles.

1. 2015 http://wwwcancerorg/acs/groups/content/@editorial/documents/document/acspc-044552pdf

2. http://ganjohojp/professional/statistics/statisticshtml#mortality 2014

3. Oncogenes and the strategy of growth factors;Baserga;Cell,1994

4. Insulin-like growth factor-I receptor as a candidate for a novel molecular target in the gastrointestinal cancers;Adachi;Dig Endosc,2006

5. The insulin-like growth factor I receptor: A key to tumor growth;Baserga;Cancer Res,1995

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