Safety, Tolerability, and Pharmacokinetics of Multiple Repeated Oral Doses of the α2/3/5‐Subtype Selective GABA A ‐Positive Allosteric Modulator PF‐06372865 in Healthy Volunteers
Author:
Affiliation:
1. Cerevel Therapeutics LLC Boston Massachusetts USA
2. Pfizer Inc. Granta Park Cambridge UK
3. Pfizer Inc. Shanghai China
4. Pfizer Inc. San Diego California USA
5. Pfizer Inc. Groton Connecticut USA
Publisher
Wiley
Subject
Pharmacology (medical),Pharmaceutical Science
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/cpdd.912
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3. Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype;McKernan RM;Nature Neurosci.,2000
4. Differential contribution of GABAA receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands;Fradley RL;J Psychopharmacol.,2007
5. Reversal of pathological pain through specific spinal GABAA receptor subtypes;Knabl J;Nature.,2008
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