The analysis of H.M.'s brain: A brief review of status and plans for future studies and tissue archive

Author:

Amaral David G.1,Augustinack Jean2,Barbas Helen34,Frosch Matthew5,Gabrieli John6,Luebke Jennifer3,Rakic Pasko7,Rosene Douglas3,Rushmore Richard J.389

Affiliation:

1. Department of Psychiatry and Behavioral Sciences The MIND Institute University of California Davis California USA

2. Department of Radiology Massachusetts General Hospital Boston Massachusetts USA

3. Department of Anatomy & Neurobiology Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA

4. Department of Health Sciences Boston University Boston Massachusetts USA

5. Department of Pathology Harvard Medical School Boston Massachusetts USA

6. Department of Brain and Cognitive Neurosciences Massachusetts Institute of Technology Cambridge Massachusetts USA

7. Departments of Neuroscience and Neurology Yale University New Haven Connecticut USA

8. Department of Psychiatry Massachusetts General Hospital Boston Massachusetts USA

9. Psychiatry Neuroimaging Department Brigham and Women's Hospital Boston Massachusetts USA

Abstract

AbstractThe famous amnesic patient Henry Molaison (H.M.) died on December 2, 2008. After extensive in situ magnetic resonance imaging in Boston, his brain was removed at autopsy and transported to the University of California San Diego. There the brain was prepared for frozen sectioning and cut into 2401, 70 μm coronal slices. While preliminary analyses of the brain sections have been reported, a comprehensive microscopic neuroanatomical analysis of the state of H.M.'s brain at the time of his death has not yet been published. The brain tissue and slides were subsequently moved to the University of California Davis and the slides digitized at high resolution. Initial stages of producing a website for the public viewing of the images were also carried out. Recently, the slides, digital images, and tissue have been transferred to Boston University for permanent archiving. A new steering committee has been established and plans are in place for completion of a freely accessible H.M. website. Research publications on the microscopic anatomy and neuropathology of H.M.'s brain at the time of his death are also planned. We write this commentary to provide the hippocampus and memory neuroscience communities with a brief summary of what has transpired following H.M.'s death and outline plans for future publications and a tissue archive.

Funder

Dana Foundation

Publisher

Wiley

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