mRNA vaccine in cancer therapy: Current advance and future outlook-Reference-Cited by-同舟云学术

mRNA vaccine in cancer therapy: Current advance and future outlook

Published:2023-08 Issue:8 Volume:13 Page:
ISSN:2001-1326
Container-title:Clinical and Translational Medicine
language:en
Short-container-title:Clinical & Translational Med

Author:

Li Youhuai¹,Wang Mina²³,Peng Xueqiang⁴,Yang Yingying⁵,Chen Qishuang²,Liu Jiaxing⁴,She Qing¹,Tan Jichao¹,Lou Chuyuan⁶,Liao Zehuan⁷⁸^ORCID,Li Xuexin⁹^ORCID

Affiliation:

1. Department of Breast Surgery Baoji Municipal Central Hospital Weibin District Baoji Shaanxi China

2. Graduate School Beijing University of Chinese Medicine Beijing China

3. Department of Acupuncture and Moxibustion Beijing Hospital of Traditional Chinese Medicine Capital Medical University Beijing Key Laboratory of Acupuncture Neuromodulation Beijing China

4. Department of General Surgery The Fourth Affiliated Hospital China Medical University Shenyang China

5. Clinical Research Center Shanghai Key Laboratory of Maternal Fetal Medicine Shanghai Institute of Maternal‐Fetal Medicine and Gynecologic Oncology Shanghai First Maternity and Infant Hospital School of Medicine Tongji University Shanghai China

6. Department of Ophthalmology Xi'an People's Hospital (Xi'an Fourth Hospital) Xi'an Shaanxi China

7. School of Biological Sciences Nanyang Technological University Singapore Singapore

8. Department of Microbiology, Tumor and Cell Biology (MTC) Karolinska Institutet Sweden

9. Department of Medical Biochemistry and Biophysics (MBB) Karolinska Institutet Biomedicum Stockholm Sweden

Abstract

AbstractMessenger ribonucleic acid (mRNA) vaccines are a relatively new class of vaccines that have shown great promise in the immunotherapy of a wide variety of infectious diseases and cancer. In the past 2 years, SARS‐CoV‐2 mRNA vaccines have contributed tremendously against SARS‐CoV2, which has prompted the arrival of the mRNA vaccine research boom, especially in the research of cancer vaccines. Compared with conventional cancer vaccines, mRNA vaccines have significant advantages, including efficient production of protective immune responses, relatively low side effects and lower cost of acquisition. In this review, we elaborated on the development of cancer vaccines and mRNA cancer vaccines, as well as the potential biological mechanisms of mRNA cancer vaccines and the latest progress in various tumour treatments, and discussed the challenges and future directions for the field.

Funder

China Postdoctoral Science Foundation

Natural Science Foundation of Liaoning Province

Publisher

Wiley

Subject

Molecular Medicine,Medicine (miscellaneous)

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ctm2.1384

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