Effectiveness and safety of reduced-dose fluoropyrimidine therapy in patients carrying the DPYD *2A variant: A matched pair analysis

Author:

Henricks Linda M.12ORCID,van Merendonk Lisanne N.12,Meulendijks Didier123,Deenen Maarten J.45,Beijnen Jos H.67,de Boer Anthonius7,Cats Annemieke8,Schellens Jan H.M.127

Affiliation:

1. Division of Pharmacology; The Netherlands Cancer Institute; Amsterdam the Netherlands

2. Department of Clinical Pharmacology, Division of Medical Oncology; The Netherlands Cancer Institute; Amsterdam the Netherlands

3. Dutch Medicines Evaluation Board (CBG-MEB); Utrecht The Netherlands

4. Department of Clinical Pharmacy, Catharina Hospital; Eindhoven The Netherlands

5. Department of Clinical Pharmacy and Toxicology; Leiden University Medical Center; Leiden the Netherlands

6. Department of Pharmacy & Pharmacology; The Netherlands Cancer Institute; Amsterdam the Netherlands

7. Division of Pharmacoepidemiology and Clinical Pharmacology, Department of Pharmaceutical Sciences; Faculty of Science, Utrecht University; Utrecht the Netherlands

8. Department of Gastrointestinal Oncology, Division of Medical Oncology; The Netherlands Cancer Institute; Amsterdam the Netherlands

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference30 articles.

1. Safety of capecitabine: a review;Mikhail;Expert Opin Drug Saf,2010

2. Dihydropyrimidine dehydrogenase (DPD) and clinical pharmacology of 5-fluorouracil (review);Milano;Anticancer Res,1994

3. Dihydropyrimidine dehydrogenase and the efficacy and toxicity of 5-fluorouracil;Van Kuilenburg;Eur J Cancer,2004

4. Lethal outcome of a patient with a complete dihydropyrimidine dehydrogenase (DPD) deficiency after administration of 5-fluorouracil: frequency of the common IVS14+1G>A mutation causing DPD deficiency;Van Kuilenburg;Clin Cancer Res,2001

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