Renal cell carcinoma in the contralateral kidney with TFE3 gene translocation following chemotherapy for childhood nephroblastoma: A case report and literature review

Author:

Fujisawa Shunsuke1ORCID,Furukawa Junya1,Hara Takuto1,Okada Keiske1,Chiba Kouji1,Nakano Yuzo1,Hyodo Toshiki2,Nagashima Yoji3,Fujisawa Masato1

Affiliation:

1. Department of Urology Kobe University Graduate School of Medicine Kobe Japan

2. Department of Diagnostic Pathology Kobe University Graduate School of Medicine Kobe Japan

3. Division of Surgical Pathology Tokyo Women's Medical University Hospital Tokyo Japan

Abstract

Key Clinical MessageRenal cell carcinoma as a secondary malignant neoplasm is relatively rare; however, the possibility of secondary renal cell carcinoma following chemoradiotherapy for childhood nephroblastoma should be considered.AbstractThe occurrence of secondary renal cell carcinoma (RCC) following chemoradiotherapy for nephroblastoma is relatively rare, especially in microphthalmia transcription factor family translocation renal cell carcinoma. A 13‐year‐old Japanese male was referred to our department for treatment of a right kidney mass. The patient had undergone open left nephrectomy and adjuvant chemotherapy for nephroblastoma, 12 years before. Diagnostic imaging revealed a tumor in the right kidney and a lesion suspected to be metastasis in the left eighth rib. Chromophobe RCC or translocation RCC was suspected from the imaging pattern. TNM classification was cT1aN0M1, and the clinical stage was IV. Partial nephrectomy by robot‐assisted surgery for the right renal tumor and resection of the left eighth rib were performed. Pathologically, the renal tumor was diagnosed as translocation RCC, and the rib lesion demonstrated no evidence of malignancy. We are currently undergoing imaging follow‐up and the patient has been recurrence‐free for 15 months. In this study, we present a rare case of secondary translocation RCC after successful treatment of nephroblastoma.

Publisher

Wiley

Subject

General Medicine

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