Microbial Phenolic Metabolites Are Associated with Improved Cognitive Health-Reference-Cited by-同舟云学术

Microbial Phenolic Metabolites Are Associated with Improved Cognitive Health

Published:2023-12-07 Issue:2 Volume:68 Page:
ISSN:1613-4125
Container-title:Molecular Nutrition & Food Research
language:en
Short-container-title:Molecular Nutrition Food Res

Author:

Domínguez‐López Inés¹²³^ORCID,Galkina Polina¹,Parilli‐Moser Isabella¹²³^ORCID,Arancibia‐Riveros Camila¹²³,Martínez‐González Miguel Ángel³⁴⁵^ORCID,Salas‐Salvadó Jordi³⁶⁷^ORCID,Corella Dolores³⁸,Malcampo Mireia⁹,Martínez J. Alfredo³¹⁰¹¹,Tojal‐Sierra Lucas³¹²,Wärnberg Julia³¹³,Vioque Jesús¹⁴¹⁵,Romaguera Dora³¹⁶,López‐Miranda José³¹⁷^ORCID,Estruch Ramon²³¹⁸,Tinahones Francisco J.³¹⁹,Santos‐Lozano José Manuel³²⁰,Serra‐Majem Lluís³²¹,Bueno‐Cavanillas Aurora¹⁶²²,Tur Josep A.³²³,Rubín‐García María²⁴^ORCID,Pintó Xavier³²⁵,Fernández‐Aranda Fernando³²⁶,Delgado‐Rodríguez Miguel¹²²⁷,Barabash‐Bustelo Ana²⁸,Vidal Josep²⁹³⁰,Vázquez Clotilde³³¹,Daimiel Lidia³³²³³^ORCID,Ros Emilio³³⁴,Toledo Estefania³⁴⁵,Atzeni Alessandro³⁶⁷,Asensio Eva M.³⁸,Vera Natàlia⁹,Garcia‐Rios Antonio³¹⁷,Torres‐Collado Laura¹⁴¹⁵,Pérez‐Farinós Napoleón³¹³,Zulet Marian³¹⁰¹¹,Chaplin Alice³¹⁶,Casas Rosa²³¹⁸^ORCID,Martín‐Peláez Sandra²²,Vaquero‐Luna Jessica³¹²,Gómez‐Pérez Ana Maria¹⁹,Vázquez‐Ruiz Zenaida³⁴⁵,Shyam Sangeetha³⁶⁷,Ortega‐Azorín Carolina³⁸,Talens Natàlia⁹,Peña‐Orihuela Patricia J.³¹⁷,Oncina‐Canovas Alejandro¹⁴¹⁵,Diez‐Espino Javier³³⁵,Babio Nancy³⁶⁷,Fitó Montserrat³⁹,Lamuela‐Raventós Rosa M.¹²³^ORCID

Affiliation:

1. Polyphenol Research Group Department of Nutrition Food Science and Gastronomy School of Pharmacy and Food Sciences Barcelona Catalunya Spain

2. Institute of Nutrition and Food Safety (INSA‐UB) University of Barcelona Santa Coloma de Gramanet 08921 Spain

3. Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN) Instituto de Salud Carlos III Madrid Spain

4. Department of Preventive Medicine and Public Health University of Navarra IDISNA Pamplona Spain

5. Department of Nutrition Harvard T.H. Chan School of Public Health Boston MA USA

6. Universitat Rovira i Virgili Departament de Bioquímica i Biotecnologia Grup de Recerca ANut‐DSM Unitat de Nutrició Reus Spain

7. Institut d'Investigació Sanitària Pere Virgili (IISPV) Reus Spain

8. Department of Preventive Medicine University of Valencia Valencia Spain

9. Unit of Cardiovascular Risk and Nutrition Institut Hospital del Mar de Investigaciones Médicas Municipal d`Investigació Médica (IMIM) Barcelona Spain

10. Department of Nutrition Food Sciences, and Physiology Center for Nutrition Research University of Navarra Pamplona Spain

11. Precision Nutrition and Cardiovascular Health IMDEA Food CEI UAM + CSIC Madrid Spain

12. Bioaraba Health Research Institute Cardiovascular, Respiratory and Metabolic Area Osakidetza Basque Health Service Araba University Hospital University of the Basque Country UPV/EHU Vitoria‐Gasteiz Spain

13. EpiPHAAN research group School of Health Sciences University of Málaga ‐ Instituto de Investigación Biomédica en Málaga (IBIMA) Málaga Spain

14. CIBER de Epidemiología y Salud Pública (CIBERESP) Instituto de Salud Carlos III (ISCIII) Madrid Spain

15. Instituto de Investigación Sanitaria y Biomédica de Alicante Universidad Miguel Hernández (ISABIAL‐UMH) Alicante Spain

16. Health Research Institute of the Balearic Islands (IdISBa) Palma de Mallorca Spain

17. Department of Internal Medicine Maimonides Biomedical Research Institute of Cordoba (IMIBIC) Reina Sofia University Hospital University of Cordoba Cordoba Spain

18. Internal Medicine Service Hospital Clínic University of Barcelona Barcelona Spain

19. Virgen de la Victoria Hospital Department of Endocrinology Instituto de Investigación Biomédica de Málaga (IBIMA) University of Málaga Málaga Spain

20. Department of Family Medicine Research Unit Distrito Sanitario Atención Primaria Sevilla Sevilla Spain

21. Research Institute of Biomedical and Health Sciences (IUIBS) University of Las Palmas de Gran Canaria & Centro Hospitalario Universitario Insular Materno Infantil (CHUIMI) Canarian Health Service Las Palmas de Gran Canaria Spain

22. Department of Preventive Medicine and Public Health University of Granada Granada Spain

23. Research Group on Community Nutrition & Oxidative Stress University of Balearic Islands Palma de Mallorca Spain

24. Group of Investigation in Interactions Gene‐Environment and Health (GIIGAS) Institute of Biomedicine (IBIOMED) Universidad de León León Spain

25. Lipids and Vascular Risk Unit Internal Medicine Hospital Universitario de Bellvitge Hospitalet de Llobregat Barcelona Spain

26. Clinical Psychology Unit University Hospital Bellvitge‐IDIBELL and University of Barcelona Barcelona Spain

27. Division of Preventive Medicine Faculty of Medicine University of Jaén Jaén Spain

28. Department of Endocrinology and Nutrition Instituto de Investigación Sanitaria Hospital Clínico San Carlos (IdISSC) Madrid Spain

29. CIBER Diabetes y Enfermedades Metabólicas (CIBERDEM) Instituto de Salud Carlos III (ISCIII) Madrid Spain

30. Department of Endocrinology Institut d` Investigacions Biomédiques August Pi Sunyer (IDIBAPS) Hospital Clinic University of Barcelona Barcelona Spain

31. Department of Endocrinology and Nutrition Hospital Fundación Jimenez Díaz Instituto de Investigaciones Biomédicas IISFJD University Autonoma Madrid Spain

32. Nutritional Control of the Epigenome Group Precision Nutrition and Obesity Program IMDEA Food CEI UAM + CSIC Madrid Spain

33. Departamento de Ciencias Farmacéuticas y de la Salud Facultad de Farmacia Universidad San Pablo‐CEU CEU Universities Urbanización Montepríncipe Boadilla del Monte 28660 Spain

34. Lipid Clinic Department of Endocrinology and Nutrition Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS) Hospital Clínic Barcelona Spain

35. Centro de Salud de Tafalla Gerencia de Atención Primaria Servicio Navarro de Salud Osasunbidea Instituto de Investigación Sanitaria de Navarra (IdiSNA) Pamplona Spain

Abstract

ScopeDiets rich in polyphenols has been associated with better cognitive performance. The aim of this study is to assess the relationship between microbial phenolic metabolites (MPM) in urine and cognition in the context of an older population at high cardiovascular risk.Methods and resultsA cross‐sectional analysis is conducted in 400 individuals of the PREDIMED‐Plus study. Liquid chromatography coupled to mass spectrometry is used to identify urinary MPM. Mediterranean diet (MedDiet) adherence is estimated with a 17‐item questionnaire and cognitive function is evaluated with a battery of neuropsychological tests. Multivariable‐adjusted linear regression models are fitted to assess the relationship of urinary MPM with the MedDiet and cognitive tests. Protocatechuic acid and enterolactone glucuronide are associated with higher adherence to the MedDiet. Regarding cognitive function, protocatechuic acid, vanillic acid glucuronide, 3‐hydroxybenzoic acid, enterodiol glucuronide, and enterolactone glucuronide are directly associated with a global composite score of all the cognitive tests. Furthermore, protocatechuic acid and enterolactone glucuronide are associated with higher scores in the Mini‐Mental State Examination, whereas enterodiol glucuronide is associated with improved Clock Drawing Test scores.ConclusionsThese results suggest that the MedDiet is linked to MPM associated with better cognitive performance in an older population.

Funder

Instituto de Salud Carlos III

Comisión Interministerial de Ciencia y Tecnología

H2020 European Research Council

American Pistachio Growers

Almond Board of California

Generalitat de Catalunya

Ministerio de Ciencia e Innovación

Institució Catalana de Recerca i Estudis Avançats

Generalitat Valenciana

European Regional Development Fund

Publisher