The effects of CYP3A4 induction and inhibition on the pharmacokinetics of alisporivir in humans

Author:

Barve Avantika1,Kovacs Steven J.1,Ke June1,Crabbe Rafael2,Grosgurin Peter2,Menetrey Annick2,Nicolas-Métral Valerie2,Dabovic Kristina1,Dole Kiran3,Zhang Jie1,Praestgaard Jens1,Sunkara Gangadhar1,Stein Daniel1

Affiliation:

1. Novartis Institutes for Biomedical Research; East Hanover NJ USA

2. Debiopharm International SA; Lausanne Switzerland

3. Novartis Institutes for Biomedical Research; Cambridge MA USA

Publisher

Wiley

Subject

Pharmacology (medical),Pharmaceutical Science

Reference12 articles.

1. An evaluation of the cyclophilin inhibitor Debio 025 and its potential as a treatment for chronic hepatitis C;Crabbe;Expert Opin Invest Drugs.,2009

2. Host-targeting agents in the treatment of hepatitis C: a beginning and an end;Baugh;Antiviral Res.,2013

3. Profile of alisporivir and its potential in the treatment of hepatitis C;Gallay;Drug Des Devel Ther.,2013

4. Pharmacokinetic and pharmacodynamic interaction study between midazolam and the macrolide antibiotics erythromycin, clarithromycin and the azalide azithromycin;Yeates;Int J Clin Pharmacol.,1996

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