Affiliation:
1. College of Traditional Chinese Medicine Chongqing Medical University Chongqing People's Republic of China
2. Graduate School Liaoning University of Traditional Chinese Medicine Shenyang People's Republic of China
3. Department of Otorhinolaryngology Yongchuan Chinese Medicine Hospital Affiliated to Chongqing Medical University Chongqing People's Republic of China
4. College of Pharmaceutical Sciences Southwest University Chongqing People's Republic of China
5. Department of Otorhinolaryngology The Affiliated Hospital of Liaoning University of Traditional Chinese Medicine Shenyang People's Republic of China
Abstract
AbstractObjectivesTo evaluate the efficacy and safety of macrolide antibiotics therapy in patients with chronic rhinosinusitis (CRS) receiving endoscopic sinus surgery.Data SourcesPubMed, Web of Science, Embase, and Cochrane Library.Review MethodsThe electronic databases were comprehensively searched on June 2, 2022, for randomized controlled trials on macrolide antibiotics in the treatment of patients undergoing CRS endoscopic surgery. The primary outcome measures were the sinonasal outcome test (SNOT) score and the visual analog scale (VAS) score. The secondary outcome measures were the nasal endoscopy score (NES), the sinus computed tomography score, and adverse events.ResultsA total of 8 studies were included, involving 606 patients who used macrolide for a long time. Meta‐analysis showed that no significant difference was observed in SNOT (standardized mean difference [SMD] = −0.13; 95% confidence interval [CI]: −0.38 to 0.13,I2 = 0%) and VAS (SMD = −0.10; 95% CI, −0.88 to 0.68,I2 = 81%) between the macrolide and placebo groups. However, macrolide outperformed the placebo in improving NES (SMD = −0.32; 95% CI, −0.62 to −0.03,I2 = 21%). The use of macrolide did not increase the incidence of adverse events.ConclusionLong‐term use of macrolide after CRS surgery may not significantly improve the quality of life and disease severity of the patients but may play a role in improving postoperative NES in patients with CRS. There is still no sufficient evidence to determine whether the disease phenotype of CRS or the patient's race will affect the efficacy of long‐term use of macrolide after CRS.
Subject
Otorhinolaryngology,Surgery
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献