Vaccination effects on reducing COVID‐19 complications in pregnancy: A large‐scale report from Iran

Author:

Changizi Nasrin1,Eshrati Babak2,Salehi Mohammadreza3ORCID,Beheshtian Maryam4,Hadipour Jahromy Leila4,Emami Afshar Nehzat4,Hejazi Saeideh4,Hantoushzadeh Sedigheh5,Eslamian Laleh6,Savaie Mohsen7,Raeisi Alireza8,Pooransari Parichehr9

Affiliation:

1. Health Research Center Tehran University of Medical Sciences Tehran Iran

2. Department of Community and Family Medicine, Preventive Medicine and Public Health Research Center Iran University of Medical Sciences Tehran Iran

3. Research Center for Antibiotic Stewardship and Anti‐microbial Resistance, Imam Khomeini Hospital Complex, Infectious Diseases Department Tehran University of Medical Sciences Tehran Iran

4. Vice Chancellery for Health, IRAN MOHME Tehran Iran

5. Department of Obstetrics and Gynecology, Family Health Research Institute, Imam Khomeini Hospital Complex Tehran University of Medical Sciences Tehran Iran

6. Department of Obstetrics and Gynecology, School of Medicine, Shariati Hospital Tehran University of Medical Sciences Tehran Iran

7. Department of Anesthesiology, School of Medicine, Pain Research Center, Razi Hospital Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran

8. Department of Internal Medicine Shiraz University of Medical Sciences Shiraz Iran

9. Department of Obstetrics and Gynecology, School of Medicine, Preventative Gynecology Research Center Shahid Beheshti University of Medical Sciences Tehran Iran

Abstract

AbstractObjectiveThe objective of this study was to evaluate the effects of maternal coronavirus disease 2019 (COVID‐19) vaccination on preventing severe complications of COVID‐19 in pregnant women.MethodsA retrospective study was conducted in pregnant women infected with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) during pregnancy and/or for up to 6 weeks postpartum between September 1, 2021, to January 30, 2022. The data was retrieved from a national database. The pregnant women were divided into two groups of vaccinated and unvaccinated. The proposed outcomes (the need for hospitalization, intensive care unit admission, and mechanical ventilation and products of conception complications) were compared between the two groups.ResultsApproximately 90 000 pregnant women infected with COVID‐19 were included in the study. The data of the vaccinated (19 922) and unvaccinated (70 147) groups were analyzed and compared. Pregnant patients in the vaccinated group had a significantly lower rate of hospitalization (21.2% vs 29.4%) (odds ratio [OR], 0.648 [95% confidence interval (CI), 0.625–0.673], P = 0.0001) and intensive care unit admission (3.7% vs 7.8%) (OR, 0.453 [95% CI, 0.382–0.535], P = 0.0001). The need for mechanical ventilation was also lower, although not statistically significant, in the vaccinated group than in the unvaccinated group (30 of 155 [19.4%] vs 418 of 1597 [26.2%]) (OR, 0.677 [95% CI, 0.448–1.024], P = 0.063). Cesarean section (54.3% vs 58.1%) (OR, 0.856 [95% CI, 0.751–0.977], P = 0.021) and stillbirth (0.4% vs 3.6%) (OR, 0.097 [95% CI, 0.026–0.252], P = 0.0001) were also significantly lower in the vaccinated patients. Most pregnant women in the vaccinated group (18 484–96.14%) received Sinopharm BIBP COVID‐19 inactivated vaccine. No significant differences were seen in the effect of different types of COVID‐19 vaccines on reducing COVID‐19 complications in infected pregnant patients.ConclusionMaternal COVID‐19 immunization is effective in reducing COVID‐19 complications in infected pregnant women.

Publisher

Wiley

Subject

Obstetrics and Gynecology,General Medicine

Reference44 articles.

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