Safety, Pharmacokinetics, and Pharmacodynamics of the ADAMTS‐5 Inhibitor GLPG1972/S201086 in Healthy Volunteers and Participants With Osteoarthritis of the Knee or Hip-Reference-Cited by-同舟云学术

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Safety, Pharmacokinetics, and Pharmacodynamics of the ADAMTS‐5 Inhibitor GLPG1972/S201086 in Healthy Volunteers and Participants With Osteoarthritis of the Knee or Hip

Published:2021-12-02 Issue:1 Volume:11 Page:112-122
ISSN:2160-763X
Container-title:Clinical Pharmacology in Drug Development
language:en
Short-container-title:Clinical Pharm in Drug Dev

Author:

Aar Ellen¹,Deckx Henri¹,Dupont Sonia²,Fieuw Ann¹,Delage Stephane²,Larsson Staffan³,Struglics André³,Lohmander L. Stefan³,Lalande Agnes⁴,Leroux Emilie⁴,Amantini David²,Passier Paul²

Affiliation:

1. Galapagos NV Mechelen Belgium

2. Galapagos SASU Romainville France

3. Department of Clinical Sciences Lund Orthopaedics Faculty of Medicine Lund University Lund Sweden

4. Institut de Recherches Internationales Servier (I.R.I.S.) Servier Suresnes France

Publisher

Wiley

Subject

Pharmacology (medical),Pharmaceutical Science

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cpdd.1042

Reference24 articles.

1. The bone–cartilage unit in osteoarthritis

2. Complete coding sequence and deduced primary structure of the human cartilage large aggregating proteoglycan, aggrecan. Human-specific repeats, and additional alternatively spliced forms.

3. Emerging Frontiers in cartilage and chondrocyte biology

4. Age-related changes in the structure of the proteoglycan subunits from human articular cartilage.

5. Proteases involved in cartilage matrix degradation in osteoarthritis

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1. New therapeutic strategies in osteoarthritis;Joint Bone Spine;2024-12

2. Targeting ADAMTS-5 for osteoarthritis: Promise and challenges;Osteoarthritis and Cartilage;2024-08

3. A phase 2b double-blind placebo-controlled randomized clinical trial of SB-061, an aggrecan mimetic, in patients with symptomatic knee osteoarthritis;Osteoarthritis and Cartilage;2024-07

4. Serum ARGS-aggrecan in a phase 2 clinical trial targeting osteoarthritis;Osteoarthritis and Cartilage;2024-06

5. From biochemical markers to molecular endotypes of osteoarthritis: a review on validated biomarkers;Expert Review of Molecular Diagnostics;2024-02

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