Parental age effects and Rett syndrome

Author:

Fang Xiaolan1ORCID,Baggett Lauren M.1,Caylor Raymond C.1ORCID,Percy Alan K.2,Neul Jeffrey L.3ORCID,Lane Jane B.2,Glaze Daniel G.4,Benke Tim A.5ORCID,Marsh Eric D.6ORCID,Motil Kathleen J.3,Barrish Judy O.4,Annese Fran E.1,Skinner Steven A.1ORCID

Affiliation:

1. Greenwood Genetic Center Greenwood South Carolina USA

2. The University of Alabama at Birmingham Birmingham Alabama USA

3. Vanderbilt Kennedy Center Vanderbilt University Medical Center Nashville Tennessee USA

4. Baylor College of Medicine Houston Texas USA

5. University of Colorado School of Medicine Children's Hospital Colorado‐Aurora Denver Colorado USA

6. Children's Hospital of Philadelphia and University of Pennsylvania Philadelphia Pennsylvania USA

Abstract

AbstractRett syndrome (RTT) is a progressive neurodevelopmental disorder, and pathogenic Methyl‐CpG‐binding Protein 2 (MECP2) variants are identified in >95% of individuals with typical RTT. Most of RTT‐causing variants in MECP2 are de novo and usually on the paternally inherited X chromosome. While paternal age has been reported to be associated with increased risk of genetic disorders, it is unknown whether parental age contributes to the risk of the development of RTT. Clinical data including parental age, RTT diagnostic status, and clinical severity are collected from 1226 participants with RTT and confirmed MECP2 variants. Statistical analyses are performed using Student t‐test, single factor analysis of variance (ANOVA), and multi‐factor regression. No significant difference is observed in parental ages of RTT probands compared to that of the general population. A small increase in parental ages is observed in participants with missense variants compared to those with nonsense variants. When we evaluate the association between clinical severity and parental ages by multiple regression analysis, there is no clear association between clinical severity and parental ages. Advanced parental ages do not appear to be a risk factor for RTT, and do not contribute to the clinical severity in individuals with RTT.

Funder

National Center for Advancing Translational Sciences

National Institute of Child Health and Human Development

National Institutes of Health

Publisher

Wiley

Subject

Genetics (clinical),Genetics

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