Stem cell–derived models to improve mechanistic understanding and prediction of human drug‐induced liver injury

Author:

Goldring Christopher1,Antoine Daniel J.1,Bonner Frank2,Crozier Jonathan3,Denning Chris4,Fontana Robert J.5,Hanley Neil A.6,Hay David C.7,Ingelman‐Sundberg Magnus8,Juhila Satu9,Kitteringham Neil1,Silva‐Lima Beatriz10,Norris Alan1,Pridgeon Chris1,Ross James A.7,Young Rowena Sison1,Tagle Danilo11,Tornesi Belen12,van de Water Bob13,Weaver Richard J.14,Zhang Fang1,Park B. Kevin1

Affiliation:

1. MRC Centre for Drug Safety Science, Department of Molecular and Clinical PharmacologyUniversity of LiverpoolLiverpool UK

2. Stem Cells for Safer MedicinesLondon UK

3. European Partnership for Alternative Approaches to Animal TestingBrussels Belgium

4. Department of Stem Cell Biology, Centre for Biomolecular SciencesUniversity of NottinghamNottingham UK

5. Division of Gastroenterology, Department of Internal MedicineUniversity of MichiganAnn Arbor MI

6. Centre for Endocrinology & Diabetes, University of Manchester, and Central Manchester University Hospitals NHS Foundation TrustManchester Academic Health Science CentreManchester UK

7. MRC Centre for Regenerative MedicineUniversity of EdinburghEdinburgh UK

8. Department of Physiology and PharmacologyKarolinska InstitutetStockholm Sweden

9. R&D, In Vitro BiologyOrion PharmaEspoo Finland

10. Faculty of PharmacyUniversidade de LisboaLisbon Portugal

11. National Center for Advancing Translational SciencesNational Institutes of HealthBethesda MD

12. Abbvie Global Pharmaceutical Research and DevelopmentNorth Chicago IL

13. Faculty of Science, Leiden Academic Centre for Drug Research, Gorlaeus LaboratoriesUniversity of LeidenLeiden The Netherlands

14. Institut de Recherches Internationales ServierSuresnes France

Funder

Medical Research Council

Stem Cells for Safer Medicines

Engineering and Physical Sciences Research Council

British Heart Foundation

Heart Research UK

National Centre for the Replacement, Refinement and Reduction of Animals in Research

Wellcome Trust

National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

Wiley

Subject

Hepatology

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